Institute of Pathogen Biology

Fei GUO Ph.D., Professor

Tel: 86-10-67855028
Email: guoafei@ipbcams.ac.cn

Research interests:

Role of host factors in virus reverse transcription during HIV replication.

Anti-virus mechanism of host factors.

Selected publications:

Hu S, Li J, Xu F, Mei S, Le Duff Y, Yin L, Pang X, Cen S, Jin Q, Liang C, Guo F: SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation. PLoS Genet 2015, 11(7):e1005367.
Li J, Xu F, Hu S, Zhou J, Mei S, Zhao X, Cen S, Jin Q, Liang C, Guo F: Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1. Biochem J 2015, 468(2):303-313.
Pang X, Hu S, Li J, Xu F, Mei S, Zhou J, Cen S, Jin Q, Guo F: Identification of novel key amino acids at the interface of the transmembrane domains of human BST-2 and HIV-1 Vpu. Retrovirology 2013, 10(1):84.
Hu S, Pang X, Li J, Cen S, Jin Q, Guo F: The role of the structural domains of human BST-2 in inhibiting the release of xenotropic murine leukemia virus-related virus. Biochem Biophys Res Commun 2012, 428(1):17-23.
Saadatmand J, Niu M, Kleiman L, Guo F: The contribution of the primer activation signal to differences between Gag- and NCp7-facilitated tRNA(Lys3) annealing in HIV-1. Virology 2009, 391(2):334-341.
Guo F, Saadatmand J, Niu M, Kleiman L: Roles of Gag and NCp7 in facilitating tRNA(Lys)(3) Annealing to viral RNA in human immunodeficiency virus type 1. J Virol 2009, 83(16):8099-8107.
Guo F, Cen S, Niu M, Yang Y, Gorelick RJ, Kleiman L: The interaction of APOBEC3G with human immunodeficiency virus type 1 nucleocapsid inhibits tRNA3Lys annealing to viral RNA. J Virol 2007, 81(20):11322-11331.
Guo F, Cen S, Niu M, Saadatmand J, Kleiman L: Inhibition of formula-primed reverse transcription by human APOBEC3G during human immunodeficiency virus type 1 replication. J Virol 2006, 80(23):11710-11722.
Guo F, Gabor J, Cen S, Hu K, Mouland AJ, Kleiman L: Inhibition of cellular HIV-1 protease activity by lysyl-tRNA synthetase. J Biol Chem 2005, 280(28):26018-26023.
Guo F, Cen S, Niu M, Javanbakht H, Kleiman L: Specific inhibition of the synthesis of human lysyl-tRNA synthetase results in decreases in tRNA(Lys) incorporation, tRNA(3)(Lys) annealing to viral RNA, and viral infectivity in human immunodeficiency virus type 1. J Virol 2003, 77(18):9817-9822.