Chen LIANG Ph.D., Distinguished visiting professor

Email: chen.liang@mcgill.ca

Research interests:
  • Understanding the interactions between HIV-1 and host cells.
  • Role of cellular helicases in various steps of HIV-1 RNA replication.

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    Selected publications:
    • Zhu W, Lei R, Le Duff Y, Li J, Guo F, Wainberg MA, Liang C: The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA. Retrovirology 2015, 12:22.
    • Hu S, Li J, Xu F, Mei S, Le Duff Y, Yin L, Pang X, Cen S, Jin Q, Liang C, Guo F: SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation. PLoS Genet 2015, 11(7):e1005367.
    • Li J, Xu F, Hu S, Zhou J, Mei S, Zhao X, Cen S, Jin Q, Liang C, Guo F: Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1. Biochem J 2015, 468(2):303-313.
    • Guo F, Liang C: Transmembrane interactions of HIV-1 Vpu and tetherin. Curr HIV Res 2012, 10(4):292-297.
    • Kuhl BD, Cheng V, Wainberg MA, Liang C: Tetherin and its viral antagonists. J Neuroimmune Pharmacol 2011, 6(2):188-201.
    • Lu J, Pan Q, Rong L, He W, Liu SL, Liang C: The IFITM proteins inhibit HIV-1 infection. J Virol 2011, 85(5):2126-2137.
    • Zhang J, Liang C: BST-2 diminishes HIV-1 infectivity. J Virol 2010, 84(23):12336-12343.
    • Zhou Y, Rong L, Zhang J, Aloysius C, Pan Q, Liang C: Insulin-like growth factor II mRNA binding protein 1 modulates Rev-dependent human immunodeficiency virus type 1 RNA expression. Virology 2009, 393(2):210-220.
    • Rong L, Zhang J, Lu J, Pan Q, Lorgeoux RP, Aloysius C, Guo F, Liu SL, Wainberg MA, Liang C: The transmembrane domain of BST-2 determines its sensitivity to down-modulation by human immunodeficiency virus type 1 Vpu. J Virol 2009, 83(15):7536-7546.
    • Pan Q, Rong L, Zhao X, Liang C: Fragile X mental retardation protein restricts replication of human immunodeficiency virus type 1. Virology 2009, 387(1):127-135.
    • Zhou Y, Rong L, Lu J, Pan Q, Liang C: Insulin-like growth factor II mRNA binding protein 1 associates with Gag protein of human immunodeficiency virus type 1, and its overexpression affects virus assembly. J Virol 2008, 82(12):5683-5692.
    • Ma J, Rong L, Zhou Y, Roy BB, Lu J, Abrahamyan L, Mouland AJ, Pan Q, Liang C: The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA. Virology 2008, 375(1):253-264.
    • Zhou Y, Ma J, Bushan Roy B, Wu JY, Pan Q, Rong L, Liang C: The packaging of human immunodeficiency virus type 1 RNA is restricted by overexpression of an RNA helicase DHX30. Virology 2008, 372(1):97-106.
    • Roy BB, Hu J, Guo X, Russell RS, Guo F, Kleiman L, Liang C: Association of RNA helicase a with human immunodeficiency virus type 1 particles. J Biol Chem 2006, 281(18):12625-12635.
    • Roy BB, Russell RS, Turner D, Liang C: The T12I mutation within the SP1 region of Gag restricts packaging of spliced viral RNA into human immunodeficiency virus type 1 with mutated RNA packaging signals and mutated nucleocapsid sequence. Virology 2006, 344(2):304-314.
    • Guo X, Roy BB, Hu J, Roldan A, Wainberg MA, Liang C: The R362A mutation at the C-terminus of CA inhibits packaging of human immunodeficiency virus type 1 RNA. Virology 2005, 343(2):190-200.
    • Guo X, Liang C: Opposing effects of the M368A point mutation and deletion of the SP1 region on membrane binding of human immunodeficiency virus type 1 Gag. Virology 2005, 335(2):232-241.
    • Guo X, Roldan A, Hu J, Wainberg MA, Liang C: Mutation of the SP1 sequence impairs both multimerization and membrane-binding activities of human immunodeficiency virus type 1 Gag. J Virol 2005, 79(3):1803-1812.
    • Liang C, Hu J, Russell RS, Kameoka M, Wainberg MA: Spliced human immunodeficiency virus type 1 RNA is reverse transcribed into cDNA within infected cells. AIDS Res Hum Retroviruses 2004, 20(2):203-211.
    • Guo X, Hu J, Whitney JB, Russell RS, Liang C: Important role for the CA-NC spacer region in the assembly of bovine immunodeficiency virus Gag protein. J Virol 2004, 78(2):551-560.
    • Russell RS, Roldan A, Detorio M, Hu J, Wainberg MA, Liang C: Effects of a single amino acid substitution within the p2 region of human immunodeficiency virus type 1 on packaging of spliced viral RNA. J Virol 2003, 77(24):12986-12995.
    • Rong L, Russell RS, Hu J, Laughrea M, Wainberg MA, Liang C: Deletion of stem-loop 3 is compensated by second-site mutations within the Gag protein of human immunodeficiency virus type 1. Virology 2003, 314(1):221-228.
    • Guo X, Kameoka M, Wei X, Roques B, Gotte M, Liang C, Wainberg MA: Suppression of an intrinsic strand transfer activity of HIV-1 Tat protein by its second-exon sequences. Virology 2003, 307(1):154-163.
    • Russell RS, Hu J, Laughrea M, Wainberg MA, Liang C: Deficient dimerization of human immunodeficiency virus type 1 RNA caused by mutations of the u5 RNA sequences. Virology 2002, 303(1):152-163.
    • Russell RS, Hu J, Beriault V, Mouland AJ, Laughrea M, Kleiman L, Wainberg MA, Liang C: Sequences downstream of the 5' splice donor site are required for both packaging and dimerization of human immunodeficiency virus type 1 RNA. J Virol 2003, 77(1):84-96.
    • Liang C, Hu J, Russell RS, Wainberg MA: Translation of Pr55(gag) augments packaging of human immunodeficiency virus type 1 RNA in a cis-acting manner. AIDS Res Hum Retroviruses 2002, 18(15):1117-1126.
    • Liang C, Hu J, Russell RS, Roldan A, Kleiman L, Wainberg MA: Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gag. J Virol 2002, 76(22):11729-11737.
    • Liang C, Wainberg MA: The role of Tat in HIV-1 replication: an activator and/or a suppressor? AIDS Rev 2002, 4(1):41-49.
    • Rong L, Russell RS, Hu J, Guan Y, Kleiman L, Liang C, Wainberg MA: Hydrophobic amino acids in the human immunodeficiency virus type 1 p2 and nucleocapsid proteins can contribute to the rescue of deleted viral RNA packaging signals. J Virol 2001, 75(16):7230-7243.
    • Liang C, Rong L, Russell RS, Wainberg MA: Deletion mutagenesis downstream of the 5' long terminal repeat of human immunodeficiency virus type 1 is compensated for by point mutations in both the U5 region and gag gene. J Virol 2000, 74(14):6251-6261.
    • Liang C, Rong L, Quan Y, Laughrea M, Kleiman L, Wainberg MA: Mutations within four distinct gag proteins are required to restore replication of human immunodeficiency virus type 1 after deletion mutagenesis within the dimerization initiation site. J Virol 1999, 73(8):7014-7020.
    • Liang C, Rong L, Cherry E, Kleiman L, Laughrea M, Wainberg MA: Deletion mutagenesis within the dimerization initiation site of human immunodeficiency virus type 1 results in delayed processing of the p2 peptide from precursor proteins. J Virol 1999, 73(7):6147-6151.
    • Liang C, Rong L, Gotte M, Li X, Quan Y, Kleiman L, Wainberg MA: Mechanistic studies of early pausing events during initiation of HIV-1 reverse transcription. J Biol Chem 1998, 273(33):21309-21315.
    • Liang C, Rong L, Laughrea M, Kleiman L, Wainberg MA: Compensatory point mutations in the human immunodeficiency virus type 1 Gag region that are distal from deletion mutations in the dimerization initiation site can restore viral replication. J Virol 1998, 72(8):6629-6636.
    • Liang C, Rong L, Morin N, Cherry E, Huang Y, Kleiman L, Wainberg MA: The roles of the human immunodeficiency virus type 1 Pol protein and the primer binding site in the placement of primer tRNA(3Lys) onto viral genomic RNA. J Virol 1997, 71(12):9075-9086.
    • Liang C, Li X, Quan Y, Laughrea M, Kleiman L, Hiscott J, Wainberg MA: Sequence elements downstream of the human immunodeficiency virus type 1 long terminal repeat are required for efficient viral gene transcription. J Mol Biol 1997, 272(2):167-177.
    • Liang C, Li X, Rong L, Inouye P, Quan Y, Kleiman L, Wainberg MA: The importance of the A-rich loop in human immunodeficiency virus type 1 reverse transcription and infectivity. J Virol 1997, 71(8):5750-5757.
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