Institute of Pathogen Biology

Qijun CHEN Ph.D. Professor

Tel: 86-10-62477735
Email: qijun.chen@ipbcams.ac.cn

Research interests:

Research on malaria pathogenesis with focus on the interactions between Plasmodium falciparum-expressed surface molecules and human erythrocytic and endothelial cells.

Research on the developmental biology of schistosome and anti-schistosomiasis vaccine.

Selected publications:

Liu S, Zhou X, Piao X, Wu C, Hou N, Chen Q: Comparative Analysis of Transcriptional Profiles of Adult Schistosoma japonicum from Different Laboratory Animals and the Natural Host, Water Buffalo. PLoS Negl Trop Dis 2015, 9(8):e0003993.
Hou N, Piao X, Liu S, Wu C, Chen Q: Tim-3 induces Th2-biased immunity and alternative macrophage activation during Schistosoma japonicum infection. Infect Immun 2015, 83(8):3074-3082.
Hou N, Piao X, Cai P, Wu C, Liu S, Xiao Y, Chen Q: A novel Schistosoma japonicum endonuclease homologous to DNase II. BMC Genomics 2015, 16:126.
Liu S, Cai P, Piao X, Hou N, Zhou X, Wu C, Wang H, Chen Q: Expression profile of the Schistosoma japonicum degradome reveals differential protease expression patterns and potential anti-schistosomal intervention targets. PLoS Comput Biol 2014, 10(10):e1003856.
Piao X, Hou N, Cai P, Liu S, Wu C, Chen Q: Genome-wide transcriptome analysis shows extensive alternative RNA splicing in the zoonotic parasite Schistosoma japonicum. BMC Genomics 2014, 15(1):715.
Cai P, Mu Y, Piao X, Hou N, Liu S, Gao Y, Wang H, Chen Q: Discovery and confirmation of ligand binding specificities of the Schistosoma japonicum polarity protein Scribble. PLoS Negl Trop Dis 2014, 8(5):e2837.
Cai P, Piao X, Liu S, Hou N, Wang H, Chen Q: MicroRNA-Gene Expression Network in Murine Liver during Schistosoma japonicum Infection. PLoS One 2013, 8(6):e67037.
Cai P, Piao X, Hao L, Liu S, Hou N, Wang H, Chen Q: A Deep Analysis of the Small Non-Coding RNA Population in Schistosoma japonicum Eggs. PLoS One 2013, 8(5):e64003.
Liu X, Song Y, Jiang N, Wang J, Tang B, Lu H, Peng S, Chang Z, Tang Y, Yin J, Liu M, Tan Y, Chen Q: Global Gene Expression Analysis of the Zoonotic Parasite Trichinella spiralis Revealed Novel Genes in Host Parasite Interaction. PLoS Negl Trop Dis 2012, 6(8):e1794.
Cai P, Piao X, Hou N, Liu S, Wang H, Chen Q: Identification and Characterization of Argonaute Protein, Ago2 and Its Associated Small RNAs in Schistosoma japonicum. PLoS Negl Trop Dis 2012, 6(7):e1745.
Liu S, Cai P, Hou N, Piao X, Wang H, Hung T, Chen Q: Genome-wide identification and characterization of a panel of house-keeping genes in Schistosoma japonicum. Mol Biochem Parasitol 2012, 182(1-2):75-82.
Liu X, Song Y, Lu H, Tang B, Piao X, Hou N, Peng S, Jiang N, Yin J, Liu M, Chen Q: Transcriptome of small regulatory RNAs in the development of the zoonotic parasite Trichinella spiralis. PLoS One 2011, 6(11):e26448.
Cai P, Hou N, Piao X, Liu S, Liu H, Yang F, Wang J, Jin Q, Wang H, Chen Q: Profiles of small non-coding RNAs in Schistosoma japonicum during development. PLoS Negl Trop Dis 2011, 5(8):e1256.
Wu C, Cai P, Chang Q, Hao L, Peng S, Sun X, Lu H, Yin J, Jiang N, Chen Q: Mapping the binding between the tetraspanin molecule (Sjc23) of Schistosoma japonicum and human non-immune IgG. PLoS One 2011, 6(4):e19112.
Piao X, Cai P, Liu S, Hou N, Hao L, Yang F, Wang H, Wang J, Jin Q, Chen Q: Global expression analysis revealed novel gender-specific gene expression features in the blood fluke parasite Schistosoma japonicum. PLoS One 2011, 6(4):e18267.
Zhang X, Wang Z, Su Y, Liang X, Sun X, Peng S, Lu H, Jiang N, Yin J, Xiang M, Chen Q: Identification and genotyping of Enterocytozoon bieneusi in China. J Clin Microbiol 2011, 49(5):2006-2008.
Jiang N, Chang Q, Sun X, Lu H, Yin J, Zhang Z, Wahlgren M, Chen Q: Co-infections with Plasmodium knowlesi and other malaria parasites, Myanmar. Emerg Infect Dis 2010, 16(9):1476-1478.
Du C, Nilsson S, Lu H, Yin J, Jiang N, Wahlgren M, Chen Q: Immunogenicity of the Plasmodium falciparum Pf332-DBL domain in combination with different adjuvants. Vaccine 2010, 28(31):4977-4983.
Jiang N, Cai P, Yin J, Hao L, Lu H, Wang X, Wang H, Chen Q: Characterization of antibody responses to the Sj23 antigen of Schistosoma japonicum after infection and immunization. Acta Trop 2010, 116(1):9-14.
Brolin KJ, Persson KE, Wahlgren M, Rogerson SJ, Chen Q: Differential recognition of P. falciparum VAR2CSA domains by naturally acquired antibodies in pregnant women from a malaria endemic area. PLoS One 2010, 5(2):e9230.
Hao L, Cai P, Jiang N, Wang H, Chen Q: Identification and characterization of microRNAs and endogenous siRNAs in Schistosoma japonicum. BMC Genomics 2010, 11:55.
Xiao Y, Yin J, Jiang N, Xiang M, Hao L, Lu H, Sang H, Liu X, Xu H, Ankarklev J, Lindh J, Chen Q: Seroepidemiology of human Toxoplasma gondii infection in China. BMC Infect Dis 2010, 10:4.
Brolin KJ, Ribacke U, Nilsson S, Ankarklev J, Moll K, Wahlgren M, Chen Q: Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites. Genome Biol 2009, 10(10):R117.
Hu Z, Yin J, Shen K, Kang W, Chen Q: Outbreaks of hemotrophic mycoplasma infections in China. Emerg Infect Dis 2009, 15(7):1139-1140.
Zhu J, Yin J, Xiao Y, Jiang N, Ankarlev J, Lindh J, Chen Q: A sero-epidemiological survey of Toxoplasma gondii infection in free-range and caged chickens in northeast China. Vet Parasitol 2008, 158(4):360-363.
Chen Q, Wang H: Implications of imaging malaria sporozoites. Trends Parasitol 2008, 24(3):106-109.
Moll K, Chene A, Ribacke U, Kaneko O, Nilsson S, Winter G, Haeggstrom M, Pan W, Berzins K, Wahlgren M, Chen Q: A novel DBL-domain of the P. falciparum 332 molecule possibly involved in erythrocyte adhesion. PLoS One 2007, 2(5):e477.
Chen Q: The naturally acquired immunity in severe malaria and its implication for a PfEMP-1 based vaccine. Microbes Infect 2007, 9(6):777-783.
Moll K, Pettersson F, Vogt AM, Jonsson C, Rasti N, Ahuja S, Spangberg M, Mercereau-Puijalon O, Arnot DE, Wahlgren M, Chen Q: Generation of cross-protective antibodies against Plasmodium falciparum sequestration by immunization with an erythrocyte membrane protein 1-duffy binding-like 1 alpha domain. Infect Immun 2007, 75(1):211-219.
Ahuja S, Pettersson F, Moll K, Jonsson C, Wahlgren M, Chen Q: Induction of cross-reactive immune responses to NTS-DBL-1alpha/x of PfEMP1 and in vivo protection on challenge with Plasmodium falciparum. Vaccine 2006, 24(35-36):6140-6154.
Flick K, Ahuja S, Chene A, Bejarano MT, Chen Q: Optimized expression of Plasmodium falciparum erythrocyte membrane protein 1 domains in Escherichia coli. Malar J 2004, 3:50.
Chen Q, Pettersson F, Vogt AM, Schmidt B, Ahuja S, Liljestrom P, Wahlgren M: Immunization with PfEMP1-DBL1alpha generates antibodies that disrupt rosettes and protect against the sequestration of Plasmodium falciparum-infected erythrocytes. Vaccine 2004, 22(21-22):2701-2712.
Rasti N, Wahlgren M, Chen Q: Molecular aspects of malaria pathogenesis. FEMS Immunol Med Microbiol 2004, 41(1):9-26.
Flick K, Chen Q: var genes, PfEMP1 and the human host. Mol Biochem Parasitol 2004, 134(1):3-9.
Chen Q, Schlichtherle M, Wahlgren M: Molecular aspects of severe malaria. Clin Microbiol Rev 2000, 13(3):439-450.
Chen Q, Heddini A, Barragan A, Fernandez V, Pearce SF, Wahlgren M: The semiconserved head structure of Plasmodium falciparum erythrocyte membrane protein 1 mediates binding to multiple independent host receptors. J Exp Med 2000, 192(1):1-10.
Chen Q, Fernandez V, Sundstrom A, Schlichtherle M, Datta S, Hagblom P, Wahlgren M: Developmental selection of var gene expression in Plasmodium falciparum. Nature 1998, 394(6691):392-395.
Chen Q, Barragan A, Fernandez V, Sundstrom A, Schlichtherle M, Sahlen A, Carlson J, Datta S, Wahlgren M: Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum. J Exp Med 1998, 187(1):15-23.