Jianwei WANG Ph.D., Professor

Tel: 86-10-67828516
Email: wangjw28@ipbcams.ac.cn

Research interests:
  • Etiology and epidemiology of infectious diseases.
  • System biology, pathogenic and susceptible mechanism of viral infectious diseases.
  • Diagnostic and preventive technology of infectious diseases and product development.

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    Selected publications:
    • Ren L, Zhang Y, Li J, Xiao Y, Zhang J, Wang Y, Chen L, Paranhos-Baccala G, Wang J: Genetic drift of human coronavirus OC43 spike gene during adaptive evolution. Sci Rep 2015, 5:11451.
    • Zhang Y, Li J, Xiao Y, Zhang J, Wang Y, Chen L, Paranhos-Baccala G, Ren L, Wang J: Genotype shift in human coronavirus OC43 and emergence of a novel genotype by natural recombination. J Infect 2015, 70(6):641-650.
    • Si Y, Li J, Niu Y, Liu X, Ren L, Guo L, Cheng M, Zhou H, Wang J, Jin Q, Yang W: Entry properties and entry inhibitors of a human H7N9 influenza virus. PLoS One 2014, 9(9):e107235.
    • Ren L, Yu X, Zhao B, Wu F, Jin Q, Zhang X, Wang J: Infection with possible precursor of avian influenza A(H7N9) virus in a child, China, 2013. Emerg Infect Dis 2014, 20(8):1362-1365.
    • Lei X, Han N, Xiao X, Jin Q, He B, Wang J: Enterovirus 71 3C Inhibits Cytokine Expression through Cleavage of the TAK1/TAB1/TAB2/TAB3 Complex. J Virol 2014, 88(17):9830-9841.
    • Xiang Z, Tsatsral S, Liu C, Li L, Ren L, Xiao Y, Xie Z, Zhou H, Vernet G, Nymadawa P, Shen K, Wang J: Respiratory infection with enterovirus genotype C117, China and Mongolia. Emerg Infect Dis 2014, 20(6):1075-1077.
    • Xiang Z, Li L, Lei X, Zhou H, Zhou Z, He B, Wang J: Enterovirus 68 3C Protease Cleaves TRIF To Attenuate Antiviral Responses Mediated by Toll-Like Receptor 3. J Virol 2014, 88(12):6650-6659.
    • Zhou Z, Gao X, Wang Y, Zhou H, Wu C, Paranhos-Baccala G, Vernet G, Guo L, Wang J: Conserved B-cell epitopes among human bocavirus species indicate potential diagnostic targets. PLoS One 2014, 9(1):e86960.
    • Zhou Z, Cao M, Guo Y, Zhao L, Wang J, Jia X, Li J, Wang C, Gabriel G, Xue Q, Yi Y, Cui S, Jin Q, Wang J, Deng T: Fragile X mental retardation protein stimulates ribonucleoprotein assembly of influenza A virus. Nat Commun 2014, 5:3259.
    • Zhou Z, Jia X, Xue Q, Ma Y, Zhao Z, Jiang Z, He B, Jin Q, Wang J: TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response. Proc Natl Acad Sci U S A 2014, 111(2):E245-254.
    • Ren L, Xiao Y, Li J, Chen L, Zhang J, Vernet G, Wang J: Multiple genomic recombination events in the evolution of saffold cardiovirus. PLoS One 2013, 8(9):e74947.
    • Xiang Z, Xie Z, Wang Z, Ren L, Xiao Y, Li L, Vernet G, Paranhos-Baccala G, Shen K, Wang J: Human enterovirus genotype C104, China. Emerg Infect Dis 2013, 19(4):689-691.
    • Wang B, Xi X, Lei X, Zhang X, Cui S, Wang J, Jin Q, Zhao Z: Enterovirus 71 Protease 2A(pro) Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses. PLoS Pathog 2013, 9(3):e1003231.
    • Guo L, Wu C, Zhou H, Paranhos-Baccala G, Vernet G, Jin Q, Wang J, Hung T: Identification of a Nonstructural DNA-Binding Protein (DBP) as an Antigen with Diagnostic Potential for Human Adenovirus. PLoS One 2013, 8(3):e56708.
    • Lei X, Xiao X, Xue Q, Jin Q, He B, Wang J: Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses. J Virol 2013, 87(3):1690-1698.
    • Xiang Z, Gonzalez R, Ren L, Xiao Y, Chen L, Zhang J, Wang W, Yang Q, Li J, Zhou H, Vernet G, Paranhos-Baccala G, Wang Z, Wang J: Prevalence and clinical characteristics of human respiratory syncytial virus in Chinese adults with acute respiratory tract infection. J Med Virol 2013, 85(2):348-353.
    • Lu G, Li J, Xie Z, Liu C, Guo L, Vernet G, Shen K, Wang J: Human metapneumovirus associated with community-acquired pneumonia in children in Beijing, China. J Med Virol 2013, 85(1):138-143.
    • Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, Hung T: TRIM38 Negatively Regulates TLR3-Mediated IFN-beta Signaling by Targeting TRIF for Degradation. PLoS One 2012, 7(10):e46825.
    • Yang Y, Wang Z, Ren L, Wang W, Vernet G, Paranhos-Baccala G, Jin Q, Wang J: Influenza A/H1N1 2009 Pandemic and Respiratory Virus Infections, Beijing, 2009-2010. PLoS One 2012, 7(9):e45807.
    • Guo L, Wang Y, Zhou H, Wu C, Song J, Li J, Paranhos-Baccala G, Vernet G, Wang J, Hung T: Differential seroprevalence of human bocavirus species 1-4 in beijing, china. PLoS One 2012, 7(6):e39644.
    • Xiang Z, Gonzalez R, Wang Z, Ren L, Xiao Y, Li J, Li Y, Vernet G, Paranhos-Baccala G, Jin Q, Wang J: Coxsackievirus A21, enterovirus 68, and acute respiratory tract infection, China. Emerg Infect Dis 2012, 18(5):821-824.
    • Li J, Ren L, Guo L, Xiang Z, Paranhos-Baccala G, Vernet G, Wang J: Evolutionary dynamics analysis of human metapneumovirus subtype A2: genetic evidence for its dominant epidemic. PLoS One 2012, 7(3):e34544.
    • Li J, Wang Z, Gonzalez R, Xiao Y, Zhou H, Zhang J, Paranhos-Baccala G, Vernet G, Jin Q, Wang J, Hung T: Prevalence of human metapneumovirus in adults with acute respiratory tract infection in Beijing, China. J Infect 2012, 64(1):96-103.
    • Guo L, Gonzalez R, Xie Z, Zhou H, Liu C, Wu C, Paranhos-Baccala G, Vernet G, Shen K, Jin Q, Wang J: Bocavirus in children with respiratory tract infections. Emerg Infect Dis 2011, 17(9):1775-1777.
    • Zhao R, Cui S, Guo L, Wu C, Gonzalez R, Paranhos-Baccala G, Vernet G, Wang J, Hung T: Identification of a highly conserved H1 subtype-specific epitope with diagnostic potential in the hemagglutinin protein of influenza A virus. PLoS One 2011, 6(8):e23374.
    • Yang J, Yang F, Ren L, Xiong Z, Wu Z, Dong J, Sun L, Zhang T, Hu Y, Du J, Wang J, Jin Q: Unbiased parallel detection of viral pathogens in clinical samples by use of a metagenomic approach. J Clin Microbiol 2011, 49(10):3463-3469.
    • Lei X, Sun Z, Liu X, Jin Q, He B, Wang J: Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol 2011, 85(17):8811-8818.
    • Ren L, Gonzalez R, Xie Z, Xiong Z, Liu C, Xiang Z, Xiao Y, Li Y, Zhou H, Li J, Yang Q, Zhang J, Chen L, Wang W, Vernet G, Paranhos-Baccala G, Shen K, Wang J: Human parainfluenza virus type 4 infection in Chinese children with lower respiratory tract infections: a comparison study. J Clin Virol 2011, 51(3):209-212.
    • Yang Y, Huang F, Gonzalez R, Wang W, Lu G, Li Y, Vernet G, Jin Q, Wang J: Evaluation of twelve real-time reverse transcriptase PCR primer-probe sets for detection of pandemic influenza A/H1N1 2009 virus. J Clin Microbiol 2011, 49(4):1434-1440.
    • Zhong H, Lei X, Qin L, Wang J, Hung T: Augmentation of adenovirus 5 vector-mediated gene transduction under physiological pH conditions by a chitosan/NaHCO3 solution. Gene Ther 2011, 18(3):232-239.
    • Xiang Z, Gonzalez R, Xie Z, Xiao Y, Liu J, Chen L, Liu C, Zhang J, Ren L, Vernet G, Paranhos-Baccala G, Shen K, Jin Q, Wang J: Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia. J Clin Virol 2010, 49(2):94-99.
    • Xiang Z, Gonzalez R, Wang Z, Xiao Y, Chen L, Li T, Vernet G, Paranhos-Baccala G, Jin Q, Wang J: Human rhinoviruses in Chinese adults with acute respiratory tract infection. J Infect 2010, 61(4):289-298.
    • Ren L, Gonzalez R, Xie Z, Xiao Y, Li Y, Liu C, Chen L, Yang Q, Vernet G, Paranhos-Baccala G, Jin Q, Shen K, Wang J: Saffold cardioviruses of 3 lineages in children with respiratory tract infections, Beijing, China. Emerg Infect Dis 2010, 16(7):1158-1161.
    • Lei X, Liu X, Ma Y, Sun Z, Yang Y, Jin Q, He B, Wang J: The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses. J Virol 2010, 84(16):8051-8061.
    • Zhiqiang W, Yaowu Y, Fan Y, Jian Y, Yongfeng H, Lina Z, Jianwei W, Qi J: Effective siRNAs inhibit the replication of novel influenza A (H1N1) virus. Antiviral Res 2010, 85(3):559-561.
    • Ren L, Gonzalez R, Xiao Y, Xu X, Chen L, Vernet G, Paranhos-Baccala G, Jin Q, Wang J: Saffold cardiovirus in children with acute gastroenteritis, Beijing, China. Emerg Infect Dis 2009, 15(9):1509-1511.
    • Guo L, Zhou H, Wang M, Song J, Han B, Shu Y, Ren L, Si H, Qu J, Zhao Z, Wang J, Hung T: A recombinant adenovirus prime-virus-like particle boost regimen elicits effective and specific immunities against norovirus in mice. Vaccine 2009, 27(38):5233-5238.
    • Ren L, Gonzalez R, Wang Z, Xiang Z, Wang Y, Zhou H, Li J, Xiao Y, Yang Q, Zhang J, Chen L, Wang W, Li Y, Li T, Meng X, Zhang Y, Vernet G, Paranhos-Baccala G, Chen J, Jin Q, Wang J: Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007. Clin Microbiol Infect 2009, 15(12):1146-1153.
    • Yang F, Ren L, Xiong Z, Li J, Xiao Y, Zhao R, He Y, Bu G, Zhou S, Wang J, Qi J: Enterovirus 71 outbreak in the People's Republic of China in 2008. J Clin Microbiol 2009, 47(7):2351-2352.
    • Ren L, Gonzalez R, Xu X, Li J, Zhang J, Vernet G, Paranhos-Baccala G, Jin Q, Wang J: WU polyomavirus in fecal specimens of children with acute gastroenteritis, China. Emerg Infect Dis 2009, 15(1):134-135.
    • Guo L, Song J, Xu X, Ren L, Li J, Zhou H, Wang M, Qu J, Wang J, Hung T: Genetic analysis of norovirus in children affected with acute gastroenteritis in Beijing, 2004-2007. J Clin Virol 2009, 44(1):94-98.
    • Xiang Z, Gonzalez R, Xie Z, Xiao Y, Chen L, Li Y, Liu C, Hu Y, Yao Y, Qian S, Geng R, Vernet G, Paranhos-Baccala G, Shen K, Jin Q, Wang J: Human rhinovirus group C infection in children with lower respiratory tract infection. Emerg Infect Dis 2008, 14(10):1665-1667.
    • Ren L, Gonzalez R, Xie Z, Zhang J, Liu C, Li J, Li Y, Wang Z, Kong X, Yao Y, Hu Y, Qian S, Geng R, Yang Y, Vernet G, Paranhos-Baccala G, Jin Q, Shen K, Wang J: WU and KI polyomavirus present in the respiratory tract of children, but not in immunocompetent adults. J Clin Virol 2008, 43(3):330-333.
    • Guo L, Wang J, Zhou H, Si H, Wang M, Song J, Han B, Shu Y, Ren L, Qu J, Hung T: Intranasal administration of a recombinant adenovirus expressing the norovirus capsid protein stimulates specific humoral, mucosal, and cellular immune responses in mice. Vaccine 2008, 26(4):460-468.
    • Zhou YM, Yang RQ, Tao SC, Li Z, Zhang Q, Gao HF, Zhang ZW, Du JY, Zhu PX, Ren LL, Zhang L, Wang D, Guo L, Wang YB, Guo Y, Zhang Y, Zhao CZ, Wang C, Jiang D, Liu YH, Yang HW, Rong L, Zhao YJ, An S, Fan XD, Wang JW, Cheng Y, Liu O, Zheng Z, Zuo HC, Shan QZ, Ruan L, Lu ZX, Hung T, Cheng J: The design and application of DNA chips for early detection of SARS-CoV from clinical samples. J Clin Virol 2005, 33(2):123-131.
    • Wang Z, Ren L, Zhao X, Hung T, Meng A, Wang J, Chen YG: Inhibition of severe acute respiratory syndrome virus replication by small interfering RNAs in mammalian cells. J Virol 2004, 78(14):7523-7527.
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