Institute of Pathogen Biology

Wei YANG Ph.D., Professor

Tel: 86-10-67872346
Email: wyang@ipbcams.ac.cn

Research interests:

Molecular mechanism of hepatitis C virus and host interaction.

Hepatitis C vaccine, small animal model and the development of anti-viral drugs.

Selected publications:

Niu Y, Si Y, Li Y, Chi X, Li X, Liu X, Li D, Cheng M, Fan J, Si S, Yang W: A novel small-molecule inhibitor of hepatitis C virus replication acts by suppressing signal transducer and activator of transcription 3. J Antimicrob Chemother 2015, 70(7):2013-2023.
Liu X, Chi X, Gong Q, Gao L, Niu Y, Cheng M, Si Y, Wang M, Zhong J, Niu J, Yang W: Association of serum level of growth differentiation factor 15 with liver cirrhosis and hepatocellular carcinoma. PLoS One 2015, 10(5):e0127518.
Si Y, Li J, Niu Y, Liu X, Ren L, Guo L, Cheng M, Zhou H, Wang J, Jin Q, Yang W: Entry properties and entry inhibitors of a human H7N9 influenza virus. PLoS One 2014, 9(9):e107235.
Cheng M, Si Y, Niu Y, Liu X, Li X, Zhao J, Jin Q, Yang W: High-Throughput Profiling of Alpha Interferon- and Interleukin-28B-Regulated MicroRNAs and Identification of let-7s with Anti-Hepatitis C Virus Activity by Targeting IGF2BP1. J Virol 2013, 87(17):9707-9718.
Zhao J, Si Y, Cheng M, Yang Y, Niu Y, Li X, Liu X, Yang W: Albumin Fusion of Interleukin-28B: Production and Characterization of Its Biological Activities and Protein Stability. PLoS One 2013, 8(5):e64301.
Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, Li X, Chen Y, Yang W: Screening and Rational Design of Hepatitis C Virus Entry Inhibitory Peptides Derived from GB Virus A NS5A. J Virol 2013, 87(3):1649-1657.
Cheng M, Si Y, Yang Y, Liu X, Gong Q, Zhao J, Niu Y, Li X, Jin Q, Yang W: Recombinant human interleukin 28B: anti-HCV potency, receptor usage and restricted cell-type responsiveness. J Antimicrob Chemother 2012, 67(5):1080-1087.
Gong Q, Cheng M, Chen H, Liu X, Si Y, Yang Y, Yuan Y, Jin C, Yang W, He F, Wang J: Phospholipid scramblase 1 mediates hepatitis C virus entry into host cells. FEBS Lett 2011, 585(17):2647-2652.
Li GR, He LY, Liu XY, Liu AP, Huang YB, Qiu C, Zhang XY, Xu JQ, Yang W, Chen YX: Rational design of peptides with anti-HCV/HIV activities and enhanced specificity. Chem Biol Drug Des 2011, 78(5):835-843.
Si Y, Liu X, Cheng M, Wang M, Gong Q, Yang Y, Wang T, Yang W: Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes. PLoS One 2011, 6(5):e19967.
Liu X, Wang T, Wakita T, Yang W: Systematic identification of microRNA and messenger RNA profiles in hepatitis C virus-infected human hepatoma cells. Virology 2010, 398(1):57-67.
Liu S, Yang W, Shen L, Turner JR, Coyne CB, Wang T: Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol 2009, 83(4):2011-2014.
Yang W, Hood BL, Chadwick SL, Liu S, Watkins SC, Luo G, Conrads TP, Wang T: Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production. Hepatology 2008, 48(5):1396-1403.
Yang W, Qiu C, Biswas N, Jin J, Watkins SC, Montelaro RC, Coyne CB, Wang T: Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus. J Biol Chem 2008, 283(13):8643-8653.
Yang W, Zhang Y, Li Y, Wu Z, Zhu D: Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3 beta pathway and is antagonized by insulin-like growth factor 1. J Biol Chem 2007, 282(6):3799-3808.
Yang W, Chen Y, Zhang Y, Wang X, Yang N, Zhu D: Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in myostatin-regulated differentiation repression. Cancer Res 2006, 66(3):1320-1326.
Yang W, Zhang Y, Ma G, Zhao X, Chen Y, Zhu D: Identification of gene expression modifications in myostatin-stimulated myoblasts. Biochem Biophys Res Commun 2005, 326(3):660-666.
Yang W, Wang K, Chen Y, Zhang Y, Huang B, Zhu DH: [Functional characterization of recombinant myostatin and its inhibitory role to chicken muscle development]. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2003, 35(11):1016-1022.