Institute of Pathogen Biology

Leiliang ZHANG Ph.D., Associate professor

Tel: 86-10-67837355
Email: zhangll@ipbcams.ac.cn

Research interests:

Interplay between hepatitis C virus and host with emphasis on membrane trafficking proteins and lipid droplets.

Mechanisms underlying control of hepatitis C virus by interferon.

Selected publications:

Hong Z, Yang X, Yang G, Zhang L: Hepatitis C virus NS5A competes with PI4KB for binding to ACBD3 in a genotype-dependent manner. Antiviral Res 2014, 107:50-55.
Li H, Yang X, Yang G, Hong Z, Zhou L, Yin P, Xiao Y, Chen L, Chung RT, Zhang L: Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment. J Virol 2014, 88(11):5956-5966.
Shao RX, Zhang L, Hong Z, Goto K, Cheng D, Chen WC, Jilg N, Kumthip K, Fusco DN, Peng LF, Chung RT: SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication. Antiviral Res 2013, 97(2):101-107.
Zhang L, Hong Z, Lin W, Shao RX, Goto K, Hsu VW, Chung RT: ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication. PLoS One 2012, 7(2):e32135.
Zhang L, Jilg N, Shao RX, Lin W, Fusco DN, Zhao H, Goto K, Peng LF, Chen WC, Chung RT: IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. J Hepatol 2011, 55(2):289-298.
Van Vliet K, Mohamed MR, Zhang L, Villa NY, Werden SJ, Liu J, McFadden G: Poxvirus proteomics and virus-host protein interactions. Microbiol Mol Biol Rev 2009, 73(4):730-749.
Zhang L, Villa NY, Rahman MM, Smallwood S, Shattuck D, Neff C, Dufford M, Lanchbury JS, Labaer J, McFadden G: Analysis of vaccinia virus-host protein-protein interactions: validations of yeast two-hybrid screenings. J Proteome Res 2009, 8(9):4311-4318.
Zhang L, Stanford M, Liu J, Barrett C, Jiang L, Barclay AN, McFadden G: Inhibition of macrophage activation by the myxoma virus M141 protein (vCD200). J Virol 2009, 83(18):9602-9607.
Zhang L, Villa NY, McFadden G: Interplay between poxviruses and the cellular ubiquitin/ubiquitin-like pathways. FEBS Lett 2009, 583(4):607-614.
Zhang L, Lee SY, Beznoussenko GV, Peters PJ, Yang JS, Gilbert HY, Brass AL, Elledge SJ, Isaacs SN, Moss B, Mironov A, Hsu VW: A role for the host coatomer and KDEL receptor in early vaccinia biogenesis. Proc Natl Acad Sci U S A 2009, 106(1):163-168.
Zhang L, Wang J, Yu M, Ru B: Functional properties of a recombinant chimeric plasminogen activator with platelet-targeted fibrinolytic and anticoagulant potential. Mol Genet Metab 2004, 82(4):304-311.
Zhang L, Wang J, Yu M, Ru B: Expression and characterization of ARSP1 from Eisenia fetida. Comp Biochem Physiol C Toxicol Pharmacol 2004, 137(2):115-122.