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Anti-virulence compounds related to VFcategory Fimbrial adhesin
(total 53 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
7-[3-methyl-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2H-isoquinolin-1-one Depiction based on curated SMILES N H OH OH OH OH O O O CH 3 Escherichia Type 1 fimbriae Preclinical (in vivo) Jarvis C, et al. 2016. ChemMedChem
(3R)-5-Oxo-6-(morpholinomethyl)-7-(1-naphthylmethyl)-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3beta-carboxylic acid lithium salt Depiction based on curated SMILES O _ O O N + Li N O H S Escherichia Type 1 fimbriae; P fimbriae Preclinical (in vivo) Pinkner JS, et al. 2006. Proc Natl Acad Sci U S A
(3R)-5-Oxo-6-(dimethylaminomethyl)-7-(1-naphthylmethyl)-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3beta-carboxylic acid lithium salt Depiction based on curated SMILES _ O N H 3 C N CH 3 + Li O H S O Escherichia Type 1 fimbriae; P fimbriae Preclinical (in vivo) Pinkner JS, et al. 2006. Proc Natl Acad Sci U S A
(3R)-5-Oxo-6-(dimethylaminomethyl)-7-methyl-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3beta-carboxylic acid lithium salt Depiction based on curated SMILES CH 3 H 3 C N _ O O + Li S H N O CH 3 Escherichia Type 1 fimbriae; P fimbriae Preclinical (in vivo) Pinkner JS, et al. 2006. Proc Natl Acad Sci U S A
(3R)-5-Oxo-6-(morpholinomethyl)-7-(1-naphthylmethyl)-8-cyclopropyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3beta-carboxylic acid lithium salt Depiction based on curated SMILES N O O N _ O O H S + Li Escherichia Type 1 fimbriae; P fimbriae Preclinical (in vivo) Pinkner JS, et al. 2006. Proc Natl Acad Sci U S A
N-methyl-3-[3-methyl-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]benzamide Depiction based on curated SMILES O OH OH HO HO H 3 C O CH 3 O NH Escherichia Type 1 fimbriae Preclinical (in vivo) Cusumano CK, et al. 2011. Sci Transl Med; Jarvis C, et al. 2016. ChemMedChem
Compound 8
(internal name in literature)		 Depiction based on curated SMILES HO O CH 3 N Vibrio TCP (Toxin-coregulated pilus) Preclinical (in vivo) Woodbrey AK, et al. 2018. Biochemistry
Phloretin Depiction based on curated SMILES HO OH OH O HO Acinetobacter
Listeria		 BfmRS
LLO (Listeriolysin O)		 Preclinical (in vitro)
Preclinical (in vivo)		 Raorane CJ, et al. 2019. Front Microbiol
Wang J, et al. 2017. Front Cell Infect Microbiol
Baicalein Depiction based on curated SMILES HO HO OH O O Listeria LLO (Listeriolysin O) Preclinical (in vivo) Wang J, et al. 2015. Sci Rep; Lu G, et al. 2019. J Cell Mol Med
Genistin Depiction based on curated SMILES H H H H O H O HO OH OH OH HO O O OH Listeria LLO (Listeriolysin O) Preclinical (in vivo) Liu M, et al. 2023. Biochem Pharmacol
   


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