Drug details:
Molecular formula: C₁₄H₁₀Cl₂N₂O₂

Standard name: N-[(E)-(3,5-dichloro-2-hydroxyphenyl)methylideneamino]benzamide

Synonyms:

N'-[(E)-(3,5-dichloro-2-hydroxyphenyl)methylidene]benzohydrazide N-[(E)-(3,5-dichloro-2-hydroxy-phenyl)methyleneamino]benzamide

Curated SMILES: O=C(N/N=C/C1=CC(Cl)=CC(Cl)=C1O)C1=CC=CC=C1

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Global effects on virulence gene regulation and effectively reduce formation of actin pedestals in vitro.
Max phase: Preclinical (in vitro)
Publications:
Tree JJ, et al., 2009. Characterization of the effects of salicylidene acylhydrazide compounds on type III secretion in Escherichia coli O157:H7. Infect Immun 77(10):4209-20.
Wang D, et al., 2011. Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds. J Biol Chem 286(34):29922-31.

Salmonella
Related VF: TTSS (SPI-1 encode); TTSS (SPI-2 encode)
Target: Not determined
Drug effect: Efficiently affected SPI1 and SPI2 activity.
Max phase: Preclinical (in vitro)
Publication:
Negrea A, et al., 2007. Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar typhimurium. Antimicrob Agents Chemother 51(8):2867-76.