VFDB - antivirulence drug 1-(tert-butyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-napthyridine-3-carboxylic acid

Acinetobacter

Aeromonas

Anaplasma

Bacillus

Bartonella

Bordetella

Brucella

Burkholderia

Campylobacter

Chlamydia

Clostridium

Corynebacterium

Coxiella

Enterococcus

Escherichia

Francisella

Haemophilus

Helicobacter

Klebsiella

Legionella

Listeria

Mycobacterium

Mycoplasma

Neisseria

Pseudomonas

Rickettsia

Salmonella

Shigella

Staphylococcus

Streptococcus

Vibrio

Yersinia

1-(tert-butyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-napthyridine-3-carboxylic acid

Drug details:
Molecular formula: C₁₃H₁₂ClFN₂O₃

Standard name: 1-tert-butyl-7-chloro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Classification: Naphthyridines; Diazanaphthalenes; Organoheterocyclic compounds; Organic compounds;

Curated SMILES: CC(C)(C)N1C=C(C(=O)O)C(=O)C2=CC(F)=C(Cl)N=C21

Chemical structure:

Acinetobacter
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits the ompA expression and biofilm formation.
Max phase: In vitro
Publication:
Na SH, et al., 2021. Screening of small molecules attenuating biofilm formation of Acinetobacter baumannii by inhibition of ompA promoter activity. J Microbiol 59(9):871-878.


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