Drug details:
Molecular formula: C₂₈H₃₀N₄O₆

Standard name: N-[(Z)-[4-ethoxy-3-[(6-oxo-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-11-yl)methyl]phenyl]methylideneamino]-3,4,5-trihydroxybenzamide

Curated SMILES: CCOC1=C(CN2CC3CC(C2)C2=CC=CC(=O)N2C3)C=C(/C=N/NC(=O)C2=CC(O)=C(O)C(O)=C2)C=C1

Evidence for compound's anti-virulence activity:

Acinetobacter
Related VFcategory: Biofilm
Target: DGC
Drug effect: Inhibits of diguanylate cyclase (DGC) enzymes that synthesize c-di-GMP that is essential for biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Sambanthamoorthy K, et al., 2014. Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development. Biofouling 30(1):17-28.

Pseudomonas
Related VFcategory: Biofilm
Target: DGC
Drug effect: Inhibits of diguanylate cyclase (DGC) enzymes that synthesize c-di-GMP that is essential for biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Sambanthamoorthy K, et al., 2014. Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development. Biofouling 30(1):17-28.