Drug details:
Molecular formula: C₁₅H₂₃N₃O₄S

Standard name: 1-tert-butyl-3-[(3,4,5-trimethoxybenzoyl)amino]thiourea

Curated SMILES: CC(C)(C)NC(=S)NNC(=O)C1=CC(=C(C(=C1)OC)OC)OC

Acinetobacter
Related VFcategory: Biofilm
Target: DGC
Drug effect: Inhibits of diguanylate cyclase (DGC) enzymes that synthesize c-di-GMP that is essential for biofilm formation.
Max phase: In vitro
Publication:
Sambanthamoorthy K, et al., 2015. Modulating Acinetobacter baumannii biofilm development with molecules containing 3,4,5-trimethoxy-N,N',N'-trimethylbenzohydrazide moiety. Bioorg Med Chem Lett 25(10):2238-42.