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(-)-Hopeaphenol

Drug details:
Molecular formula: C56H42O12

Classification: 2-arylbenzofuran flavonoids; Phenylpropanoids and polyketides; Organic compounds;
Synonyms:  Hopeaphenol
(1R)-1alpha,7alpha-Bis(4-hydroxyphenyl)-6beta-[(1R)-1alpha,7alpha-bis(4-hydroxyphenyl)-4,8,10-trihydroxy-1,6,7,11balpha-tetrahydrobenzo[6,7]cyclohepta[1,2,3-cd]benzofuran-6beta-yl]-1,6,7,11balpha-tetrahydrobenzo[6,7]cyclohepta[1,2,3-cd]benzofuran-4,8,10-triol

Chemical structure:
Depiction based on curated SMILES HO O OH HO HO OH OH O HO HO OH OH

Pseudomonas
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Inhibits T3SS.
Max phase: In vivo
Publication:
Zetterström CE, et al., 2013. The resveratrol tetramer (-)-hopeaphenol inhibits type III secretion in the gram-negative pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa. PLoS One 8(12):e81969.

Yersinia
Related VF: TTSS (Type III secretion system)
Target: Targets possibly are located on the bacterial cell surface
Drug effect: An irreversible inhibitor of Yop secretion.
Max phase: In vivo
Publication:
Zetterström CE, et al., 2013. The resveratrol tetramer (-)-hopeaphenol inhibits type III secretion in the gram-negative pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa. PLoS One 8(12):e81969.








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