Drug details:
Molecular formula: C₂₀H₃₀N₂O₂

Standard name: 3-cyclohexyl-1-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-one

Synonym:

3-cyclohexyl-1-[4-(2-methoxyphenyl)piperazino]-1-propanone

Curated SMILES: COC1=CC=CC=C1N1CCN(C(=O)CCC2CCCCC2)CC1

Clostridium
Related VF: TcdB (Toxin B)
Target: Calcium channels on the plasma membrane
Drug effect: Disrupts of TcdB-induced calcium signaling thus to ablate ROS production and prevent subsequent necrosis.
Max phase: In vitro
Publication:
Farrow MA, et al., 2020. Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis. ACS Chem Biol 15(5):1212-1221.