Drug details:
Molecular formula: C₂₈H₂₃NO₂

Standard name: 7,7-dimethyl-10-naphthalen-1-yl-5,6,8,10-tetrahydroindeno[1,2-b]quinoline-9,11-dione

Synonyms:

7,7-dimethyl-10-(1-naphthalenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione 7,7-dimethyl-10-(naphthalen-1-yl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione

Curated SMILES: CC1(CC2=C(C(C3=C(N2)C4=CC=CC=C4C3=O)C5=CC=CC6=CC=CC=C65)C(=O)C1)C

Clostridium
Related VF: TcdB (Toxin B)
Target: Calcium channels on the plasma membrane
Drug effect: Disrupts of TcdB-induced calcium signaling thus to ablate ROS production and prevent subsequent necrosis.
Max phase: In vitro
Publication:
Farrow MA, et al., 2020. Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis. ACS Chem Biol 15(5):1212-1221.