Drug details:
Molecular formula: C₁₈H₂₁N₃O₆S

Standard name: (2S,3S)-N-hydroxy-3-methyl-2-[[3-(4-nitrophenyl)phenyl]sulfonylamino]pentanamide

Curated SMILES: CCC(C)C(NS(=O)(=O)C1=CC=CC(C2=CC=C([N+](=O)[O-])C=C2)=C1)C(=O)NO

Clostridium
Related VF: BoNT (Botulinum neurotoxin)
Target: BoNT/A LC
Drug effect: Inhibits BoNT/A light chain (LC), a zinc metalloprotease that cleaves SNARE proteins.
Max phase: In vitro
Publication:
Thompson JC, et al., 2020. Synthesis and activity of isoleucine sulfonamide derivatives as novel botulinum neurotoxin serotype A light chain inhibitors. Bioorg Med Chem 28(18):115659.