Drug details:
Molecular formula: C₂₀H₂₂N₂O₅S

Standard name: (2S)-2-[[3-(1-benzofuran-2-yl)phenyl]sulfonylamino]-N-hydroxyhexanamide

Curated SMILES: CCCC[C@H](NS(=O)(=O)C1=CC=CC(C2=CC3=C(C=CC=C3)O2)=C1)C(=O)NO

Clostridium
Related VF: BoNT (Botulinum neurotoxin)
Target: BoNT/A LC
Drug effect: Inhibits BoNT/A light chain (LC), a zinc metalloprotease that cleaves SNARE proteins.
Max phase: In vitro
Publication:
Thompson JC, et al., 2020. Synthesis and activity of isoleucine sulfonamide derivatives as novel botulinum neurotoxin serotype A light chain inhibitors. Bioorg Med Chem 28(18):115659.