Drug details:
Molecular formula: C₁₉H₂₀Cl₂N₂O₃

Standard name: 3-(2,5-dichlorophenyl)-N-[(2S,3S)-1-(hydroxyamino)-3-methyl-1-oxopentan-2-yl]benzamide

Curated SMILES: CCC(C)C(NC(=O)C1=CC=CC(C2=CC(Cl)=CC=C2Cl)=C1)C(=O)NO

Clostridium
Related VF: BoNT (Botulinum neurotoxin)
Target: BoNT/A LC
Drug effect: Inhibits BoNT/A light chain (LC), a zinc metalloprotease that cleaves SNARE proteins.
Max phase: In vitro
Publication:
Thompson JC, et al., 2020. Synthesis and activity of isoleucine sulfonamide derivatives as novel botulinum neurotoxin serotype A light chain inhibitors. Bioorg Med Chem 28(18):115659.