Drug details:
Molecular formula: C₂₁H₂₂N₂O₄

Standard name: 3-(1-benzofuran-2-yl)-N-[(2R)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]benzamide

Curated SMILES: CC(C)C[C@@H](NC(=O)C1=CC=CC(C2=CC3=CC=CC=C3O2)=C1)C(=O)NO

Clostridium
Related VF: BoNT (Botulinum neurotoxin)
Target: BoNT/A LC
Drug effect: Inhibits BoNT/A light chain (LC), a zinc metalloprotease that cleaves SNARE proteins.
Max phase: In vitro
Publication:
Thompson JC, et al., 2020. Synthesis and activity of isoleucine sulfonamide derivatives as novel botulinum neurotoxin serotype A light chain inhibitors. Bioorg Med Chem 28(18):115659.