Drug details:
Classification: Benzimidazoles; Organoheterocyclic compounds; Organic compounds;

Curated SMILES: OCCCC1=NC2=C(Cl)C=C(C(F)(F)F)C=C2N1

Vibrio
Related VFcategory: Post-translational modification
Target: DsbA
Drug effect: Binds to the hydrophobic groove of oxidized DsbA enzymes involved in the functional folding and secretion of virulence factors, including CT and TCP.
Max phase: In vitro
Publication:
Wang G, et al., 2022. Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacterials. ChemMedChem 17(6):e202100673.