Drug details:
Molecular formula: C₂₀H₁₁NO₃S

Standard name: N-(4-oxothieno[3,4-c]chromen-3-yl)-3-phenylprop-2-ynamide

Curated SMILES: O=C(C#CC1=CC=CC=C1)NC1=C2C(=O)OC3=CC=CC=C3C2=CS1

Vibrio
Related VF: HlyU
Target: HlyU
Drug effect: Inhibits the binding of HlyU to its target promoter DNA thus reduces HlyU-dependent expression of virulence genes including vvhA, rtxA, plpA, ect.
Max phase: In vivo
Publication:
Lee ZW, et al., 2019. Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species. Sci Rep 9(1):4346.