Drug details:
Classification: Tetralins; Benzenoids; Organic compounds;

Curated SMILES: CCCCC1=CC=CC2=C1C(CCC(=O)O)CCC2

Vibrio
Related VF: TCP (Toxin-coregulated pilus)
Target: ToxT
Drug effect: Inhibits ToxT, an AraC family regulator that binds the tcpA and ctx promoters and directly activates virulence gene expression.
Max phase: In vitro
Publication:
Woodbrey AK, et al., 2018. A Modified ToxT Inhibitor Reduces Vibrio cholerae Virulence in Vivo. Biochemistry 57(38):5609-5615.