Drug details:
Molecular formula: C₁₇H₂₆N₄O₃S₂

Standard name: N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(oxolan-2-ylmethyldisulfanyl)pent-2-en-2-yl]formamide

Synonyms:

Alinamin F Thiamine tetrahydrofurfuryl disulfide Thiamin tetrahydrofurfuryl disulfide Diteftin Alinamin-f Aliaron F Judolor fursultiamine hydrochloride Linamin ......

Curated SMILES: CC1=NC=C(CN(C=O)/C(C)=C(\CCO)SSCC2CCCO2)C(N)=N1

Vibrio
Related VF: HlyU
Target: HlyU
Drug effect: Inhibits the transcription of the highly invasive repeat-in-toxin (rtxA1) and hemolysin (vvhA) along with other HlyU regulated virulence genes.
Max phase: In vivo
Publication:
Imdad S, et al., 2018. Identification and Validation of an Antivirulence Agent Targeting HlyU-Regulated Virulence in Vibrio vulnificus. Front Cell Infect Microbiol 8:152.