VFDB - antivirulence drug 2-(2-Pyridin-3-yl-vinyl)-3-m-tolyl-3H-quinazolin-4-one

Acinetobacter

Aeromonas

Anaplasma

Bacillus

Bartonella

Bordetella

Brucella

Burkholderia

Campylobacter

Chlamydia

Clostridium

Corynebacterium

Coxiella

Enterococcus

Escherichia

Francisella

Haemophilus

Helicobacter

Klebsiella

Legionella

Listeria

Mycobacterium

Mycoplasma

Neisseria

Pseudomonas

Rickettsia

Salmonella

Shigella

Staphylococcus

Streptococcus

Vibrio

Yersinia

2-(2-Pyridin-3-yl-vinyl)-3-m-tolyl-3H-quinazolin-4-one

Drug details:
Molecular formula: C₂₂H₁₇N₃O

Standard name: 3-(3-methylphenyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one

Classification: Benzodiazines; Diazanaphthalenes; Organoheterocyclic compounds; Organic compounds;

Curated SMILES: CC1=CC(=CC=C1)N2C(=NC3=CC=CC=C3C2=O)/C=C/C4=CN=CC=C4

Chemical structure:

Klebsiella
Related VF: Aerobactin
Target: IucA
Drug effect: Inhibits aerobactin synthetase IucA activity.
Max phase: In vitro
Publication:
Bailey DC, et al., 2018. Development of a High-Throughput Biochemical Assay to Screen for Inhibitors of Aerobactin Synthetase IucA. SLAS Discov 23(10):1070-1082.


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