VFDB - antivirulence drug N-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-yl-2,3-dihydro-1H-benzimidazol-5-yl)-N'-(3,4-dimethylphenyl)urea

Acinetobacter

Aeromonas

Anaplasma

Bacillus

Bartonella

Bordetella

Brucella

Burkholderia

Campylobacter

Chlamydia

Clostridium

Corynebacterium

Coxiella

Enterococcus

Escherichia

Francisella

Haemophilus

Helicobacter

Klebsiella

Legionella

Listeria

Mycobacterium

Mycoplasma

Neisseria

Pseudomonas

Rickettsia

Salmonella

Shigella

Staphylococcus

Streptococcus

Vibrio

Yersinia

N-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-yl-2,3-dihydro-1H-benzimidazol-5-yl)-N'-(3,4-dimethylphenyl)urea

Drug details:
Molecular formula: C₂₂H₂₇N₅O₂

Standard name: 1-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-3-(3,4-dimethylphenyl)urea

Classification: N-phenylureas; Benzene and substituted derivatives; Benzenoids; Organic compounds;

Curated SMILES: CC1=CC=C(NC(=O)NC2=CC3=C(C=C2N2CCCC2)N(C)C(=O)N3C)C=C1C

Chemical structure:

Yersinia
Related VF: TTSS (Type III secretion system)
Target: Yops
Drug effect: Inhibits translocation of Yop effectors.
Max phase: In vitro
Publication:
Harmon DE, et al., 2010. Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis. Antimicrob Agents Chemother 54(8):3241-54.


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