VFDB - antivirulence drug (E)-2-hydroxy-5-(5-(3-((1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)amino)-3-oxoprop-1-en-1-yl)furan-2-yl)benzoic acid

Acinetobacter

Aeromonas

Anaplasma

Bacillus

Bartonella

Bordetella

Brucella

Burkholderia

Campylobacter

Chlamydia

Clostridium

Corynebacterium

Coxiella

Enterococcus

Escherichia

Francisella

Haemophilus

Helicobacter

Klebsiella

Legionella

Listeria

Mycobacterium

Mycoplasma

Neisseria

Pseudomonas

Rickettsia

Salmonella

Shigella

Staphylococcus

Streptococcus

Vibrio

Yersinia

(E)-2-hydroxy-5-(5-(3-((1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)amino)-3-oxoprop-1-en-1-yl)furan-2-yl)benzoic acid

Drug details:
Molecular formula: C₂₃H₂₇N₂O₆

Standard name: CHEMBL227379

Classification: Fatty acids and conjugates; Fatty Acyls; Lipids and lipid-like molecules; Organic compounds;

Curated SMILES: CC1(C)CC(NC(=O)/C=C/C2=CC=C(C3=CC(C(=O)O)=C(O)C=C3)O2)CC(C)(C)N1[O-]

Chemical structure:

Yersinia
Related VF: TTSS secreted effectors
Target: YopH
Drug effect: Targets the phosphotyrosine-binding pocket of YopH.
Max phase: In vitro
Publication:
Leone M, et al., 2010. NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH. Chem Biol Drug Des 76(1):10-6.


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