Drug details:
Molecular formula: C₂₂H₂₃NO₇

Standard name: 7-[3-methyl-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2H-isoquinolin-1-one

Curated SMILES: CC1=C(C=CC(=C1)C2=CC3=C(C=C2)C=CNC3=O)OC4C(C(C(C(O4)CO)O)O)O

Escherichia
Related VF: Type 1 fimbriae
Target: FimH
Drug effect: Bound to the FimH lectin domain to interfere with bacterial adhesion, invasion and biofilm formation.
Max phase: In vivo
Publication:
Jarvis C, et al., 2016. Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI. ChemMedChem 11(4):367-73.