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dimethyl 5-[4-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]benzene-1,3-dicarboxylate

Drug details:
Molecular formula: C22H24O10

Classification: Carbohydrates and carbohydrate conjugates; Organooxygen compounds; Organic oxygen compounds; Organic compounds;
Chemical structure:
Depiction based on curated SMILES H H H H O H HO HO HO OH O O CH 3 O O CH 3 O

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: Type 1 fimbriae
Target: FimH
Drug effect: Bound to the FimH lectin domain to interfere with bacterial adhesion, invasion and biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Han Z, et al., 2010. Structure-based drug design and optimization of mannoside bacterial FimH antagonists. J Med Chem 53(12):4779-92.








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