Drug details:
Molecular formula: C₃₀H₅₀O₂

Standard name: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol

Synonyms:

Betulinol Betuline Trochol Betulol Betulinic alcohol Lup-20(29)-ene-3beta,28-diol Lup-20(29)-ene-3b,28-diol (+)-betulin Lup-20(30)-ene-3beta,28-diol ......

Curated SMILES: CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)CO

Listeria
Related VF: LLO (Listeriolysin O)
Target: LLO
Drug effect: Betulin obviously inhibited Lm-induced cell injury in vitro and protected against infection in vivo through an antivirulence effect.
Max phase: In vivo
Publication:
Lu G, et al., 2019. Betulin efficiently suppresses the process of an experimental Listeria monocytogenes infection as an antagonist against listeriolysin O. Fitoterapia 139:104409.