Drug details:
Molecular formula: C₁₆H₁₃Cl₂N₅O

Standard name: 1-[3-(2-amino-1H-imidazol-5-yl)phenyl]-3-(3,4-dichlorophenyl)urea

Curated SMILES: C1=CC(=CC(=C1)NC(=O)NC2=CC(=C(C=C2)Cl)Cl)C3=CN=C(N3)N

Francisella
Related VFcategory: Regulation
Target: QseB
Drug effect: Binds with high affinity to QseB to hinder its DNA-binding activity thus to impede the initiation of downstream events such as theformation of biofilms, protective responses, and virulence factors.
Max phase: In vitro
Publication:
Milton ME, et al., 2017. Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. Mol Microbiol 106(2):223-235.