Listeria
Related VF: LLO (Listeriolysin O)
Target: SrtA;LLO
Drug effect: Inhibits the peptidase activity of SrtA and the hemolytic activity of LLO.
Max phase: In vivo
Publication: Liu M, et al., 2023. Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro. Biochem Pharmacol 209:115447.