Drug details:
Molecular formula: C₂₀H₂₁N₃O₂

Standard name: (3S)-3-amino-4-(1H-imidazol-5-yl)-1-(4-phenylmethoxyphenyl)butan-2-one

Synonym:

(S)-3-amino-1-(4-(benzyloxy)phenyl)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride

Curated SMILES: N[C@@H](CC1=CNC=N1)C(=O)CC1=CC=C(OCC2=CC=CC=C2)C=C1

Brucella
Related VFcategory: Others
Target: Histidinol dehydrogenase (HDH)
Drug effect: Inhibits HDH activity to interfere with histidine biosynthesis which is essential for intramacrophagic replication.
Max phase: In vitro
Publication:
Abdo MR, et al., 2011. Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors. Org Biomol Chem 9(10):3681-90.