Drug details:
Molecular formula: C₂₄H₁₇F₃N₂O₂

Standard name: (4Z)-2-phenyl-4-[(3-phenylmethoxyphenyl)methylidene]-5-(trifluoromethyl)pyrazol-3-one

Curated SMILES: C1=CC=C(C=C1)COC2=CC=CC(=C2)/C=C\3/C(=NN(C3=O)C4=CC=CC=C4)C(F)(F)F

Haemophilus
Related VF: LOS
Target: LgtC
Drug effect: Inhibits α-1,4-galactosyltransferase LgtC.
Max phase: In vitro
Publication:
Xu Y, et al., 2018. Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC. Bioorg Med Chem 26(11):2973-2983.