Drug details:
Molecular formula: C₁₇H₁₁F₃N₂O

Standard name: (4Z)-4-benzylidene-2-phenyl-5-(trifluoromethyl)pyrazol-3-one

Curated SMILES: C1=CC=C(C=C1)/C=C\2/C(=NN(C2=O)C3=CC=CC=C3)C(F)(F)F

Haemophilus
Related VF: LOS
Target: LgtC
Drug effect: Inhibits α-1,4-galactosyltransferase LgtC.
Max phase: In vitro
Publication:
Xu Y, et al., 2018. Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC. Bioorg Med Chem 26(11):2973-2983.