Drug details:
Molecular formula: C₁₃H₈N₄O₃

Standard name: (3E)-3-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,4-tricarbonitrile

Curated SMILES: N#CC(C#N)=C/C(N)=C(\C#N)C1=CC(O)=C(O)C(O)=C1

Mycobacterium
Related VFcategory: Exoenzyme
Target: SapM
Drug effect: Inhibits a secreted alkaline phosphatase SapM activity to reduce intracellular mycobacterial survival in host macrophages.
Max phase: In vitro
Publication:
Fernández-Soto P, et al., 2021. Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis. Sci Rep 11(1):7667.