Drug details:
Molecular formula: C₁₇H₁₄N₄O₄

Standard name: N-(2-methyl-5-nitrophenyl)-2-(4-oxoquinazolin-3-yl)acetamide

Curated SMILES: CC1=CC=C([N+](=O)[O-])C=C1NC(=O)CN1C=NC2=C(C=CC=C2)C1=O

Mycobacterium
Related VFcategory: Immune modulation
Target: CdnP
Drug effect: Inhibits bacterial phosphodiesterase (PDE) CdnP activity that responsible for cleaving bacterial c-di-AMP as well as host-derived cGAMP to blunt the host's response to infection.
Max phase: In vitro
Publication:
Karanja CW, et al., 2021. Identification of a Mycobacterium tuberculosis Cyclic Dinucleotide Phosphodiesterase Inhibitor. ACS Infect Dis 7(2):309-317.