Drug details:
Molecular formula: C₁₁H₉ClN₂O₂S

Standard name: 2-(3-chlorophenyl)-4-methoxy-5-sulfanylpyridazin-3-one

Synonym:

2-(3-chlorophenyl)-4-methoxy-5-sulfanylpyridazin-3(2h)-one

Curated SMILES: COC1=C(C=NN(C1=O)C2=CC(=CC=C2)Cl)S

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: In vitro
Publication:
Suree N, et al., 2009. Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorg Med Chem 17(20):7174-85.