Drug details:
Molecular formula: C₁₇H₁₂Br₃N₃S

Standard name: 5-methyl-2-phenyl-4-[(2,4,6-tribromophenyl)iminomethyl]-1H-pyrazole-3-thione

Curated SMILES: CC1=C(C(=S)N(N1)C2=CC=CC=C2)C=NC3=C(C=C(C=C3Br)Br)Br

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: In vitro
Publication:
Suree N, et al., 2009. Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorg Med Chem 17(20):7174-85.