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5-[[(2e)-3-(2-furyl)prop-2-enoyl]amino]-2-morpholin-4-ylbenzoic acid

Drug details:
Molecular formula: C18H18N2O5

Classification: Benzoic acids and derivatives; Benzene and substituted derivatives; Benzenoids; Organic compounds;
Chemical structure:
Depiction based on curated SMILES O N OH O O N H O

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: In vitro
Publication:
Chenna BC, et al., 2010. Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors. Eur J Med Chem 45(9):3752-61.








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