Drug details:
Molecular formula: C₂₀H₂₂N₂O₃S

Standard name: methyl 2-piperidin-1-yl-5-[[(E)-3-thiophen-2-ylprop-2-enoyl]amino]benzoate

Curated SMILES: COC(=O)C1=C(C=CC(=C1)NC(=O)/C=C/C2=CC=CS2)N3CCCCC3

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: In vitro
Publication:
Chenna BC, et al., 2010. Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors. Eur J Med Chem 45(9):3752-61.