Drug details:
Molecular formula: C₁₅H₉N₇S

Standard name: 6-(3H-benzimidazol-5-yl)-3-pyridin-4-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Curated SMILES: C1=CC(C2=NN=C3SC(C4=CC=C5NC=NC5=C4)=NN32)=CC=N1

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: In vivo
Publication:
Zhang J, et al., 2014. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. Proc Natl Acad Sci U S A 111(37):13517-22.