Clostridium
Related VF: theta-toxin/PFO (Perfringolysin O)
Target: PFO
Drug effect: Blocks Perfringolysin O (PFO)-binding to cholesterol-containing membranes and subsequent pore formation to prevent PFO-mediated cytolysis and cell death during infection.
Max phase: In vitro
Publication: Aziz UBA, et al., 2024. Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins. Nat Commun 15(1):3537.
Streptococcus
Related VF: Pneumolysin
Target: PLY
Drug effect: Blocks Pneumolysin (PLY)-binding to cholesterol-containing membranes and subsequent pore formation to prevent PLY-mediated cytolysis and cell death during infection.
Max phase: In vitro
Publication: Aziz UBA, et al., 2024. Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins. Nat Commun 15(1):3537.