Drug details:
Molecular formula: C₁₉H₁₈O

Standard name: (4E,6E)-1,7-diphenylhepta-4,6-dien-3-one

Synonyms:

(4E,6E)-1,7-diphenylhepta-4,6-dien-3-one (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one HEP-DIENE-ONE DER FR ALPINA KATSUMANDAI 1,7-diphenylhepta-4,6-dien-3-one 4,6-Heptadien-3-one, 1,7-diphenyl- (E,E)-1,7-Diphenyl-4,6-heptadien-3-one DAH-3-keto-4,6-dien trans,trans-1,7-diphenyl-1,3-heptadien-5-one (4E,6E)-1,7-diphenyl-hepta-4,6-dien-3-one ......

Curated SMILES: C1=CC=C(C=C1)CCC(=O)/C=C/C=C/C2=CC=CC=C2

Streptococcus
Related VF: Pneumolysin
Target: PLY;SrtA
Drug effect: Inhibits SrtA-mediated adesion and biofilm formation; suppresses the oligomerization process of Pneumolysin (PLY) to inhibit PLY-mediated hemolysis activity.
Max phase: In vivo
Publication:
Zhang C, et al., 2022. Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A. Fitoterapia 162:105261.