Drug details:
Classification: Tetrahydrofuran lignans; Furanoid lignans; Lignans, neolignans and related compounds; Organic compounds;

Curated SMILES: COC1=CC(C[C@H]2COC(=O)[C@@H]2CC2=CC(OC)=C(O)C(O)=C2)=CC(O)=C1O

Evidence for compound's anti-virulence activity:

Streptococcus
Related VFcategory: Others; Adherence; Biofilm
Target: SrtA
Drug effect: Inhibits SrtA-mediated adesion and biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Cho E, et al., 2022. Inhibition of Streptococcus mutans adhesion and biofilm formation with small-molecule inhibitors of sortase A from Juniperus chinensis. J Oral Microbiol 14(1):2088937.