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| T6SS |
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T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii. ... |
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| T6SS |
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A phagetail-spike-like injectisome to translocate virulence determinants directly into the host cell cytoplasm. Four effectors of the T6SS have so far been characterized, Hcp1, Vgr1, Vgr2 and Vgr3. Hcp is a powerful effector substrate and once translocated into the targeted host cell cytoplasm, apoptosis ensues following caspase 3 activation. Hcp paralyzes macrophages to prevent phagocytosis. Vgr1 is an ADP-ribosylating toxin capable of interrupting the host cell cytoskeleton and inducing apoptosis. ... |
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| T6SS-1 |
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Burkholderia pseudomallei possessing six copies of T6SSs. Essential for virulence and plays an important role in the intracellular lifestyle of B. pseudomallei. In B. mallei, the T6SS cluster homologous to B. pseudomallei T6SS-1, is important for actin-based motility, multinucleated giant cell formation, intracellular growth in murine macrophages, and virulence in hamsters. ... |
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| T6SS |
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Phylogenetic analysis of T6SSs lead to the classification of the F. tularensis T6SS as a unique subtype T6SSii. Representatives of T6SSi are widespread among Proteobacteria, whereas T6SSiii have so far been identified only in Bacteroidetes. Out of the 13 proteins that define the core of prototypical T6SSs, the FPI lacks obvious homologues for at least 5 of them. A TssM/IcmF family protein (PdpB) lacks the conserved Walker A box required to bind ATP and to provide energy to the secretion process. Francisella VgrG protein is much smaller than prototypical VgrG proteins. The atypical T6SS might be linked to its unique ability to target the eukaryotic phagosomal membrane. ... |
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| T6SS |
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Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1–Tle5. The Tle1–Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif. ... |
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HSI-1
(Hcp secretion island I) |
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HSI-1 is highly homologous to a group of genes found in many Gram-negative proteobacteria that have been termed the IcmF-associated homologous protein (IAHP) cluster and encodes a secretory system that may play a general role in mediating host interaction. ... |
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| HSI-2 |
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P. aeruginosa encodes three distinct T6SS loci, H1- to H3-T6SS. While H1-T6SS has only been involved in antibacterial activity so far, H2-T6SS and H3-T6SS can target both bacterial and eukaryotic cells possessing even as said earlier trans-kingdom effectors. ... |
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| HSI-3 |
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The expression of T6SSs in P. aeruginosa is regulated by the QS system. There are several QS systems in P. aeruginosa, two N-acyl-homoserine lactone based QS systems (las and rhl systems) and one quinolone PQS system (pqs). The expression of H1-T6SS is negatively regulated by both las and pqs QS systems, while the expression of H2- and H3-T6SS is positively regulated by las, rhl, and pqs. ... |
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| SCI (Salmonella centrisome island)/SPI-6 T6SS |
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The T6SS is widely distributed in all Salmonella species and subspecies. Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
i2, i3 and i4a of the known T6SS subtypes. Salmonella T6SSs were acquired from horizontal gene transfer events and could be lost during evolution. ... |
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T6SS
(Type VI secretion system) |
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Plays a role in interbacterial competition and host colonization. T6SS encoded by chromosome in S. sonnei gives S. sonnei an advantage in a niche-specific enviroment over E. coli, S. flexneri and other closely related species. T6SS predominate S. sonnei colonization in host and help it during interbacterial competition. ... |
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