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PbpG
(Penicillin-binding protein) |
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Penicillin-binding proteins (PBPs) are most commonly associated with binding to and inactivating b-lactam antibiotics. PBPs also participate in the final steps of the biosynthesis of the peptidoglycan layer and thus contribute to bacterial cell stability. ... |
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Brk
(Bordetella resistance to killing) |
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The brk locus was also found in B. parapertussis and B. bronchiseptica but not B. avium. ... |
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| BBK32 |
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Unique in its ability to specifically target the classical pathway of complement. The only known inhibitor which directly blocks the initiator protease C1r. ... |
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| CspA |
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Also known as Complememt Regulator Acquiring Surface Protein 1, CRASP-1 or BBA68 of in B. burgdorferi strain B31. The only member of the Pfam54 gene family to exhibit host-specific Factor H-binding. CspA-mediated, FH binding-dependent complement evasion drives Lyme borreliae host tropism. CspA bound more strongly to FHL-1 than to FH. CspA is expressed by the Borrelia spirochetes in the mammalian host only at the tick biting site , but not during later stages of the infection. ... |
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| CspZ |
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Also known as Complememt Regulator Acquiring Surface Protein 2, CRASP-2 and BBH06 in B. burgdorferi strain B31. In contrast to CspA, the CspZ protein has been shown to be expressed by the spirochetes only during mammalian infection, whereas, CspA is being expressed particularly during the tick-host and host-tick transmissions. A polymorphic CspZ motif within the FH- binding interface modulates pathogen host tropism. ... |
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ErpA/C/P
(OspE/F-related protein (erp)) |
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Almost all spirochetes in the genus Borrelia (sensu lato) naturally contain multiple variants of closely related prophages. In the Lyme disease borreliae, these
prophages are maintained as circular episomes that are called circular plasmid 32kb (cp32s). The cp32s of Lyme agents are particularly unique in that they encode two
distinct families of lipoproteins, namely, Erp and Rev, that are expressed on the bacterial outer surface during infection of vertebrate hosts. Strain B31 carries three identical copies of erpA, on cp32-1, cp32-5, and cp32-8, and one copy each of erpC and erpP on cp32-2 and cp32-9, respectively. The ErpA(CRASP-5, complement regulator-acquiring surface protein-5), ErpC(CRASP-4), and ErpP(CRASP-3) proteins are very similar to each other, sharing approximately 90% amino acid sequence identities. ... |
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OspC
(Outer surface protein C) |
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A high degree of genetic variation at the ospC locus. At least 25 different ospC alleles have been identified to date, with extensive diversity occurring even within B. burgdorferi isolates within limited geographical regions. ... |
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| fHbp |
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PDB code: 3KVD. Binds complment factor H to prevent complement-mediated killing. ... |
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NspA
(Neisserial surface protein A) |
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PDB code: 1P4T. Binds complement factor H to inhibit host innate immune defenses. ... |
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Adr1
(Adhesion of Rickettsiae protein 1) |
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An integral outer-membrane protein containing eight membrane-embedded β-strands and four "loop" regions that are exposed to extracellular milieu. Belongs to a family of gram-negative outer membrane proteins embodied by E. coli OmpX. Some members of this protein family, namely Yersinia enterolitica Ail and Salmonella typhimurium Rck. ... |
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