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(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[(5Z)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-4-oxo-2-phenylimino-1,3-thiazolidin-3-yl]-3-(4-phenylphenyl)propanoyl]amino]pentanamide

Drug details:
Molecular formula: C39H41N7O6S

Classification: Amino acids, peptides, and analogues; Carboxylic acids and derivatives; Organic acids and derivatives; Organic compounds;
Chemical structure:
Depiction based on curated SMILES O N H H HN HN NH 2 NH 2 O O O CH 3 OH O S N H 3 C N H

Evidence for compound's anti-virulence activity:

Salmonella
Related VF: TTSS (SPI-1 encode)
Target: May targeting secretin protein
Drug effect: Inhibits bacterial secretion systems in a wide array of animal and plant pathogens.
Max phase: Preclinical (in vitro)
Publication:
Felise HB, et al., 2008. An inhibitor of gram-negative bacterial virulence protein secretion. Cell Host Microbe 4(4):325-36.








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