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N-(4-amino-2-methyl-6-quinolinyl)-N-{2-[(4-amino-2-methyl-6-quinolinyl)amino]-6-methyl-4-pyrimidinyl}amine

Drug details:
Molecular formula: C25H24N8

Classification: Aminoquinolines and derivatives; Quinolines and derivatives; Organoheterocyclic compounds; Organic compounds;
Synonym:  6-N-[2-[(4-amino-2-methylquinolin-6-yl)amino]-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine

Chemical structure:
Depiction based on curated SMILES N NH N CH 3 NH 2 N CH 3 NH 2 H 3 C N N H

Evidence for compound's anti-virulence activity:

Salmonella
Related VF: TTSS (SPI-1 encode)
Target: Not determined
Drug effect: Decreases secretion of T3SS proteins.
Max phase: Preclinical (in vitro)
Publication:
von Ambüren J, et al., 2020. Comprehensive Host Cell-Based Screening Assays for Identification of Anti-Virulence Drugs Targeting Pseudomonas aeruginosa and Salmonella Typhimurium. Microorganisms 8(8):1096.








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