Drug details:
Molecular formula: C₁₀H₁₄N₂O

Standard name: 4-morpholin-4-ylaniline

Synonyms:

4-morpholinobenzenamine 4-morpholin-4-ylaniline p-Morpholinoaniline 4-Morpholin-4-yl-phenylamine N-(4-Aminophenyl)morpholine 4-(morpholin-4-yl)aniline 4-(4-Morpholino)aniline Benzenamine, 4-(4-morpholinyl)- 4-Morpholinyl aniline ......

Curated SMILES: NC1=CC=C(N2CCOCC2)C=C1

Evidence for compound's anti-virulence activity:

Salmonella
Related VF: TTSS (SPI-1 encode)
Target: SipD
Drug effect: Interacts with the Salmonella tip protein SipD to inhibit T3SS secretion.
Max phase: Preclinical (in vitro)
Publication:
McShan AC, et al., 2016. Characterization of the Binding of Hydroxyindole, Indoleacetic acid, and Morpholinoaniline to the Salmonella Type III Secretion System Proteins SipD and SipB. ChemMedChem 11(9):963-71.

Shigella
Related VF: TTSS (Type III secretion system)
Target: IpaD
Drug effect: Inhibits transcriptional activator.
Max phase: Preclinical (in vitro)
Publication:
Dey S, et al., 2017. Characterization of Small-Molecule Scaffolds That Bind to the Shigella Type III Secretion System Protein IpaD. ChemMedChem 12(18):1534-1541.