Drug details:
Molecular formula: C₂₀H₃₈N₄O

Standard name: 4-(2-amino-1H-imidazol-5-yl)-N-tridecylbutanamide

Curated SMILES: CCCCCCCCCCCCCNC(=O)CCCC1=CNC(N)=N1

Evidence for compound's anti-virulence activity:

Acinetobacter
Related VF: BfmRS
Target: BfmR
Drug effect: Binds to BfmR, a response regulator that is the master controller of biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Thompson RJ, et al., 2012. Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry 51(49):9776-8.

Streptococcus
Related VFcategory: Biofilm
Target: VicR
Drug effect: Binds to VicR and inhibits expression of vicR and VicR-regulated genes, including the genes that encode the key biofilm matrix producing enzymes, Gtfs in S.mutans.
Max phase: Preclinical (in vivo)
Publication:
Liu C, et al., 2023. Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator. mBio 14(3):e0013723.