Drug details:
Molecular formula: C₁₅H₁₄O₅

Standard name: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one

Synonyms:

Dihydronaringenin 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one Phloretol 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)- beta-(p-Hydroxyphenyl)phloropropiophenone 2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone EINECS 200-488-7 ......

Curated SMILES: O=C(CCC1=CC=C(O)C=C1)C1=C(O)C=C(O)C=C1O

Evidence for compound's anti-virulence activity:

Acinetobacter
Related VF: BfmRS
Target: BfmR
Drug effect: Binds to BfmR, a response regulator that is the master controller of biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Raorane CJ, et al., 2019. Antibiofilm and Antivirulence Efficacies of Flavonoids and Curcumin Against Acinetobacter baumannii. Front Microbiol 10:990.

Listeria
Related VF: LLO (Listeriolysin O)
Target: Hly
Drug effect: Inhibits LLO expression and neutralizes SrtA catalytic activity.
Max phase: Preclinical (in vivo)
Publication:
Wang J, et al., 2017. Phloretin Attenuates Listeria monocytogenes Virulence Both In vitro and In vivo by Simultaneously Targeting Listeriolysin O and Sortase A. Front Cell Infect Microbiol 7:9.